Clinical Proof
Studies on Psylium Husk
Psyllium Husk
A multi-site, randomized, double-blind, parallel-design study of 170 subjects with chronic idiopathic constipation involved a 2-week baseline (placebo) phase followed by 2 weeks of treatment.
The treatment phase compared psyllium (5.1 g b.d.) plus docusate placebo to docusate sodium (100 mg b.d.) plus psyllium placebo. Stools were collected and assessed. RESULTS: Compared to baseline, psyllium increased stool water content vs. docusate. Psyllium also increased stool water weight , total stool output, and O'Brien rank-type score combining objective measures of constipation.
Bowel movement (BM) frequency was significantly greater for psyllium (3.5 BM/week) vs. docusate (2.9 BM/week) in treatment week 2 (P = 0.02), with no significant difference between treatment groups in treatment week 1. Psyllium is superior to docusate sodium for softening stools by increasing stool water content, and has greater overall laxative efficacy in subjects with chronic idiopathic constipation.
Resources
Aliment Pharmacol Ther. 1998 May;12(5):491-7.
McRorie JW. The Procter & Gamble Company, Cincinnati, Ohio 45224, USA.
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